Research is currently experimenting with a drug and using more sophisticated methods in Anserm. Researchers have proved that humans are tolerant and well tolerated. It is not yet time to prove that it is effective

French researchers are testing a new antihypertensive drug that inhibits the action of an enzyme involved in hypertension. In France, more than 10% of the population would be affected by high blood pressure

Hypertension affects about one-third of people over the age of 50 and is one of the leading causes of consultation in general practice. As its name suggests, it is defined by high blood pressure (or blood pressure). Over time, it damages the arteries, shortens the heart and can lead to many cardiovascular problems. In general, doctors advocate a low salt diet and encourage weight loss in case of overweight. These healthy eating habits can also be accompanied by medication.

In a study published in the journal Clinical Pharmacokinetics, Inserm researchers have just developed a new antihypertensive drug called RB150 / QGC001, which has a different mode of action than other drugs. It inhibits aminopeptidase A, an enzyme that converts angiotensin II into the brain into angiotensin III. The second boosts blood pressure in three different ways. It increases blood levels of an antidiuretic hormone called vasopressin, improves the activity of sympathetic neurons associated with vessel vasoconstriction, and inhibits baroreflex, a physiological response that lowers blood pressure. "These three mechanisms contribute, independently of each other, to increase blood pressure," says Catherine Llorens-Cortes, co-author of the study.blood pressure

The blood pressure monitor is used to calculate the blood pressure (or blood pressure). The tensions are expressed in millimeters of mercury (Hg). Physicians consider that there is high blood pressure for systolic bloodpressure values ​​above 140 mmHg or diastolic blood pressure above 90 mmHg.

Antihypertensive with novel mode of action

The new antihypertensive, by blocking the synthesis of angiotensin III, should therefore limit the risk of hypertension in humans. "It's a bit of a three-in-one medicine," says the researcher. The molecule is currently actively developing. Phase I has just ended with convincing results on healthy volunteers. This step consisted in verifying the good tolerance of the administered molecule in a single dose (phase Ia) then in repeated doses for seven days (phase Ib). In both studies, the drug was well tolerated, which opens the door to a Phase IIa clinical trial in hypertensive patients.

This new step involves comparing the efficacy and safety of the new inhibitor with that of a placebo and an already known antihypertensive drug. The results will be available at the end of 2015. In the meantime, the team of Catherine Llorens-Cortes continues to search for new and more effective It is very possible that aminopeptidase A helps inhibitors of hypertensive patients better control the condition.

Women by their nature should always be elegant but some women win the title of elegance and others fail, although they may make money and follow more tips.

What is the secret behind the permanent elegance, which does not change despite the passage of years? How are you stylish today and tomorrow and after several years? How do you look in the future as a stylish lady despite the fact that "fashion" is over?

In this article the most important tips that make women elegant in all occasions and times even after the passage of decades: 

Standard color

'Simplicity is elegance' is a phrase we have always heard but we often ignore it to try to install parts on parts or colors on the colors, yet the golden advice for those who want to get a permanent elegance to be careful to wear clothes of one color or the most different degrees of color One.

Wear what suits you not what you love

The first key to lasting elegance is to wear what suits you, not what you love; it does not matter what color you prefer, the taste you give it, the design you want, or the brand you want to own.

Invest in what suits you and look for it even if it is contrary to what you prefer and if you do not find among the ready-made clothes commensurate with your size, length and the nature of your body look for a knight to make you what suits you.

Simple inscriptions

There are three elements that are always used in the pattern of women's clothing and are often lines, flowers and squares and sometimes they are mixed to get a new composition, and the advice here is that when wearing embroidered clothes the pattern should be simple in two colors only light blue and white, or white and black .

Modern accessories and shoes

Although the elegance of the permanent always tends to the classic look conservative, but it is not possible to ignore the accessories and modern shoes that give a striking touch of clothes and show beauty, but the purchase of shoes and accessories are expensive and modern may be a good investment in terms of saving money.

Jewelery and jewelery

We can not talk about how women are elegant in all occasions without mentioning the need to appear with some pieces of jewelry and heritage inherited from a family member, if not by buying.

The classic pieces of jewelry give a wonder

fool look to women and their appeal is especially attractive in social events and formal gatherings.

Men's clothes always work

Have you ever wondered why men's clothes have not developed much in the past 100 years? The reason is that they have reached a certain level of permanent elegance that satisfies the tastes of men and thus the suit, jacket, shirt, shirt and jeans have become a standard for the elegant man.

The men's wardrobe also includes some men's clothing for holiday and family events, which will add a new look to it.